Article
Frequent polymorphism in BCR exon b2 identified in BCR-ABL positive and negative individuals using fluorescent hybridization probes.
Leukemia - 1 Nov 2000
Saussele S, Weisser A, Müller M C, Emgi M, La Rosée P, Paschka P, Kuhn C, Willer A, Hehlmann R, Hochhaus A
Abstract excerpt
Recently, a polymorphic base in exon 13 of the BCR gene (exon b2 of the major breakpoint cluster region) has been identified in the eighth position before the junctional region of BCR-ABL cDNA. Cytosine replaces thymidine; the corresponding triplets are AAT (T allele) and AAC (C allele), respectively, both coding for asparagine. Therefore, this polymorphism has no implication in the primary structure of BCR and...
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