CGG-repeat polymorphism of the BCR gene rules out predisposing alleles leading to the Philadelphia chromosome.

doi:10.1002/gcc.2870090211

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Article

CGG-repeat polymorphism of the BCR gene rules out predisposing alleles leading to the Philadelphia chromosome.

Genes, chromosomes & cancer - 1 Feb 1994

Riggins G J, Sherman S L, Phillips C N, Stock W, Westbrook C A, Warren S T

Abstract excerpt

The Philadelphia chromosome (Ph) is associated with leukemia, most frequently of the chronic myelogenous variety. The Ph chromosome is a translocation chromosome which gains oncogenic potential through the fusion of the ABL oncogene of chromosome 9 with the BCR gene of chromosome 22. The Ph is be...

Topics

Alleles
Base Sequence
Gene Frequency
Genes, abl
Genetic Predisposition to Disease
Hematologic Diseases
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Molecular Sequence Data
Neoplasms
Philadelphia Chromosome
Polymorphism, Genetic
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcr
Proto-Oncogenes
Repetitive Sequences, Nucleic Acid

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Open in PubMed

Identifiers

PMID: 7513545
DOI: 10.1002/gcc.2870090211

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7513545-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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