Article
No evidence for involvement of type 1 collagen structural genes in 'genetic predisposition' to alcoholic cirrhosis.
Journal of hepatology - 1 Nov 1992
Bashir R, Day C P, James O F, Ogilvie D J, Sykes B, Bassendine M F
Abstract excerpt
Type 1 collagen is the predominant collagen in cirrhotic livers. Each type 1 collagen molecule contains three subunits, two are identical (the alpha 1 chains) and the sequence of the third (alpha 2) is very similar. They are encoded at the non-synthenic loci, COL1A1 and COL1A2 and restriction site dimorphisms have been described at each locus. Genetic factors have been invoked as a basis for increased...
Topics
- Collagen
- Genes
- Genotype
- Haplotypes
- Humans
- Liver Cirrhosis, Alcoholic
- Polymorphism, Restriction Fragment Length