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Article

Tumour necrosis factor-beta gene RFLP alleles in Finnish IDDM haplotypes. The Childhood Diabetes in Finland (DiMe) Study Group.

Scandinavian journal of immunology - 1 Dec 1992

Ilonen J, Merivuori H, Reijonen H, Knip M, Akerblom H K, Pociot F, Nerup J

Abstract excerpt

The genes located between class II and class I HLA genes including polymorphic tumour necrosis factor (TNF) genes may contribute to the disease susceptibility in IDDM. Restriction fragment polymorphisms of the TNF-beta gene have been found to be fixed in the major IDDM susceptibility haplotypes, the B62,DR4 haplotype being associated with the 10.5-kb fragment and the B8,DR3 haplotype with a 5.5-kb fragment. We...

Topics

Alleles
Diabetes Mellitus, Type 1
Finland
Gene Frequency
Genetic Predisposition to Disease
HLA-DR Antigens
Haplotypes
Humans
Immunophenotyping
Lymphotoxin-alpha
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1361076
DOI: 10.1111/j.1365-3083.1992.tb03139.x

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1361076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Tumour necrosis factor-beta gene RFLP alleles in Finnish IDDM haplotypes. The Childhood Diabetes in Finland (DiMe) Study Group.PMID 1361076Read ↗

Multi-locus analysis of HLA class II genes in DR2-positive IDDM haplotypes in Finland. The "Childhood Diabetes in Finland" (DiMe) Study Group.Semantic proximity Read ↗

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