Article
Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus.
Lancet (London, England) - 28 Nov 1992
Katagiri H, Asano T, Ishihara H, Inukai K, Anai M, Miyazaki J, Tsukuda K, Kikuchi M, Yazaki Y, Oka Y
Abstract excerpt
A nonsense mutation at codon 186 in exon 5 of the gene for glucokinase, an enzyme important for glucose-induced insulin secretion, was identified in a Japanese patient with late-onset non-insulin-dependent diabetes mellitus (NIDDM). All affected members of her family were heterozygous for the mut...
Topics
- Adolescent
- Adult
- Blood Glucose
- Body Mass Index
- Codon
- Diabetes Mellitus, Type 2
- Exons
- Female
- Genetic Carrier Screening
- Genetic Linkage
- Glucokinase
- Glucose Tolerance Test
- Humans
- Male
- Middle Aged
- Mutation
- Pedigree
- Polymerase Chain Reaction