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Classical Swine Fever Virus Leader Proteinase N pro Is Not Required for Viral Replication in Cell Culture

1 Sept 1998

Abstract excerpt

The sequence encoding the viral leader proteinase Npro was replaced by the murine ubiquitin gene in a full-length cDNA clone of the classical swine fever virus (CSFV) strain Alfort/187. The recombinant virus vA187-Ubi showed growth characteristics similar to those of the parent vA187-1 virus. At two occasions cells infected with vA187-Ubi exhibited a cytopathic effect and were found to contain a subgenomic viral...

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Identifiers

PMID: 9696875
DOI: 10.1128/jvi.72.9.7681-7684.1998

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