Article
Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy.
Annals of neurology - 1 Aug 2009
Verbeek Marcel M, Kremer Berry P H, Rikkert Marcel Olde, Van Domburg Peter H M F, Skehan Maureen E, Greenberg Steven M
Abstract excerpt
Cerebral amyloid angiopathy is caused by deposition of the amyloid beta protein in the cerebral vasculature. In analogy to previous observations in Alzheimer disease, we hypothesized that analysis of amyloid beta(40) and beta(42) proteins in the cerebrospinal fluid might serve as a molecular biomarker. We observed strongly decreased cerebrospinal fluid amyloid beta(40) (p < 0.01 vs controls or Alzheimer disease)...
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