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Article

Absence of selection of HIV-1 variants in vivo based on transcription/transactivation during progression to AIDS.

Virology - 1 Jun 1992

Delassus S, Meyerhans A, Cheynier R, Wain-Hobson S

Abstract excerpt

The activity of the human immunodeficiency virus type 1 (HIV-1) transactivation protagonists tat and TAR has been analyzed from sequential primary material. The sequences were amplified from uncultured peripheral blood mononuclear cells. Despite fluctuations within the tat and TAR quasispecies there was no obvious selection for a variant encoding more powerful transactivation components either in vivo or ex vivo,...

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Identifiers

PMID: 1350126
DOI: 10.1016/0042-6822(92)90536-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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