Article
Absence of selection of HIV-1 variants in vivo based on transcription/transactivation during progression to AIDS.
Virology - 1 Jun 1992
Delassus S, Meyerhans A, Cheynier R, Wain-Hobson S
Abstract excerpt
The activity of the human immunodeficiency virus type 1 (HIV-1) transactivation protagonists tat and TAR has been analyzed from sequential primary material. The sequences were amplified from uncultured peripheral blood mononuclear cells. Despite fluctuations within the tat and TAR quasispecies th...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- CD4-Positive T-Lymphocytes
- Gene Expression Regulation, Viral
- Genes, tat
- Genetic Variation
- HIV Long Terminal Repeat
- HIV-1
- Humans
- Leukocyte Count
- Molecular Sequence Data
- Promoter Regions, Genetic
- Selection, Genetic
- Time Factors
- Transcription, Genetic
- Transcriptional Activation