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Article

In vitro selection of HIV-1 TAR variants by the Tat protein.

Journal of biotechnology - 15 Apr 1998

Marozzi A, Meneveri R, Giacca M, Gutierrez M I, Siccardi A G, Ginelli E

Abstract excerpt

Starting from a pool of 10(13) RNA sequences, we isolated a number of TAR RNA variants after nine rounds of selection by binding to recombinant Tat in vitro (SELEX procedure). Sequence analysis of part of the selected molecular species indicated that two TAR variants (clones A and B) were, respectively, represented five and four times. These two groups of sequences constituted approximately 25% of the total...

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Identifiers

PMID: 9654745
DOI: 10.1016/s0168-1656(98)00017-0

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