Article
Depletion of CD8(+) T cells in vivo impairs host defense of mice resistant and susceptible to pulmonary paracoccidioidomycosis.
Infection and immunity - 1 Jan 2000
Cano L E, Singer-Vermes L M, Costa T A, Mengel J O, Xidieh C F, Arruda C, André D C, Vaz C A, Burger E, Calich V L
Abstract excerpt
Using a pulmonary model of infection, we demonstrated previously that A/Sn and B10.A mice are, respectively, resistant and susceptible to Paracoccidioides brasiliensis infection. Employing the same experimental model, we examined herein the role of CD8(+) T cells in the course of paracoccidioidomycosis. Treatment with anti-CD8 monoclonal antibodies caused a selective depletion of pulmonary and splenic CD8(+) T...
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