Article
A point mutation in the thymidine kinase gene is responsible for acyclovir-resistance in herpes simplex virus type 2 sequential isolates.
Virus research - 1 Sept 1992
Palù G, Gerna G, Bevilacqua F, Marcello A
Abstract excerpt
A number of HSV-2 isolates, sequentially recovered from ulcerative ano-genital lesions of an AIDS patient during a prolonged treatment with acyclovir (ACV), have been studied at the molecular level. All of them were highly resistant to ACV (ACV-r) and shown to be virtually deficient in thymidine kinase (TK) activity. The ACV-r phenotype was demonstrated to be due to the production of truncated TK polypeptide....
Topics
- Acquired Immunodeficiency Syndrome
- Acyclovir
- Adult
- Base Sequence
- DNA, Viral
- Drug Resistance, Microbial
- Genes, Viral
- Herpes Genitalis
- Humans
- Male
- Molecular Sequence Data