Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene.

doi:10.2337/diab.41.11.1473

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Article

Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene.

Diabetes - 1 Nov 1992

Taylor S I

Abstract excerpt

Insulin resistance contributes to the pathogenesis of NIDDM. We have investigated the molecular mechanisms of insulin resistance in patients with genetic syndromes caused by mutations in the insulin-receptor gene. In general, patients with two mutant alleles of the insulin-receptor gene are more...

Topics

Amino Acid Sequence
Diabetes Mellitus, Type 2
Exons
Genetic Diseases, Inborn
Humans
Insulin Resistance
Mutation
Protein-Tyrosine Kinases
RNA, Messenger
Receptor, Insulin
Sequence Deletion
Syndrome

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