Article
Mutations in insulin-receptor gene in insulin-resistant patients.
Diabetes care - 1 Mar 1990
Taylor S I, Kadowaki T, Kadowaki H, Accili D, Cama A, McKeon C
Abstract excerpt
Defects in insulin-receptor function have been associated with insulin-resistant states such as obesity and non-insulin-dependent diabetes mellitus (NIDDM). Several types of mutations in the insulin-receptor gene have been identified in patients with genetic syndromes of extreme insulin resistance. In some patients, insulin resistance results from a decrease in the number of insulin receptors on the cell surface....
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