Article
Mutations in insulin-receptor gene in insulin-resistant patients.
Diabetes care - 1 Mar 1990
Taylor S I, Kadowaki T, Kadowaki H, Accili D, Cama A, McKeon C
Abstract excerpt
Defects in insulin-receptor function have been associated with insulin-resistant states such as obesity and non-insulin-dependent diabetes mellitus (NIDDM). Several types of mutations in the insulin-receptor gene have been identified in patients with genetic syndromes of extreme insulin resistance. In some patients, insulin resistance results from a decrease in the number of insulin receptors on the cell surface....
Topics
- Base Sequence
- Codon
- Diabetes Mellitus, Type 2
- Female
- Genes
- Humans
- Insulin Resistance
- Male
- Mutation
- Polymorphism, Restriction Fragment Length
- Receptor, Insulin