Alpha 2 adrenergic receptor subtypes in depression: a candidate gene study.

doi:10.1016/0165-0327(92)90005-q

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Article

Alpha 2 adrenergic receptor subtypes in depression: a candidate gene study.

Journal of affective disorders - 1 Jul 1992

Wang Z, Crowe R R, Tanna V L, Winokur G

Abstract excerpt

Alpha 2 adrenergic receptors play an important role in regulating the neuronal release of norepinephrine through presynaptic feedback inhibition in the locus ceruleus. Therefore, alpha 2 adrenergic autoreceptors may underlie some aspects of the pathogenesis and symptomatic expression of depressiv...

Topics

Adult
Brain
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 2
Cloning, Molecular
Depressive Disorder
Female
Genetic Linkage
Humans
Male
Models, Genetic
Mutation
Receptors, Adrenergic

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