Article
Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2004
Abou Jamra Rami, Schumacher Johannes, Golla Astrid, Richter Carola, Otte Andreas C J, Schulze Thomas G, Ohlraun Stephanie, Maier Wolfgang, Rietschel Marcella, Cichon Sven, Propping Peter, Nöthen Markus M
Abstract excerpt
Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for alpha-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The alpha(1c)-adrenergic (ADRA-1C) receptor gene on 8p21, the alpha(2a)-adrenergic (ADRA-2A) receptor gene on 10q25, and the alpha(2c)-adrenergic...
Topics
- 5' Untranslated Regions
- Bipolar Disorder
- Child
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 8
- Disease Transmission, Infectious
- Family
- Female