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Article

The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers.

Psychopharmacology - 1 Jan 2006

Martín-Guerrero Idoia, Callado Luis F, Saitua Koldo, Rivero Guadalupe, García-Orad Africa, Meana J Javier

Abstract excerpt

RATIONALE: alpha(2A)-Adrenoceptor up-regulation and supersensitivity have been described in the postmortem brains of depressed suicide victims and in the platelets of depressed subjects. The C to G transversion at nucleotide 753 (Asn to Lys change at amino acid 251 or N251K) is a low-frequency polymorphism of the alpha(2A)-adrenoceptor gene that results in a gain-of-function phenotype. A previous study has...

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Source

Identifiers

PMID: 16333651
DOI: 10.1007/s00213-005-0266-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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