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Article

Functional analysis of human papillomavirus type 16 E7 by complementation with adenovirus E1A mutants.

The Journal of general virology - 1 Aug 1992

Davies R C, Vousden K H

Abstract excerpt

Functional analysis of human papillomavirus type 16 E7 protein by complementation with adenovirus E1A mutants in baby rat kidney cells has shown that the retinoblastoma gene product (RB)-binding region of E7 can substitute in trans for that of E1A. An N-terminal E7 mutant was unable to complement an E1A mutant unable to bind p300, indicating that the two mutants were defective for functionally equivalent...

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Source

Identifiers

PMID: 1322963
DOI: 10.1099/0022-1317-73-8-2135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional analysis of human papillomavirus type 16 E7 by complementation with adenovirus E1A mutants.PMID 1322963Read ↗

Complementation of a p300/CBP defective-binding mutant of adenovirus E1a by human papillomavirus E6 proteins.Semantic proximity Read ↗

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.Semantic proximity Read ↗

Inactivation of the RB1 and PTPN14 tumor suppressors cooperatively enables the carcinogenic activity of the human papillomavirus E7 oncoproteinSemantic proximity Read ↗

Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequencesSemantic proximity Read ↗

Analysis of human papillomavirus type 16 open reading frame E7 immortalizing function in rat embryo fibroblast cells.Semantic proximity Read ↗

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.Semantic proximity Read ↗

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteinsSemantic proximity Read ↗

Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells.Semantic proximity Read ↗

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity.Semantic proximity Read ↗

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.Semantic proximity Read ↗

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.Semantic proximity Read ↗

Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.Semantic proximity Read ↗

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