Functional analysis of human papillomavirus type 16 E7 by complementation with adenovirus E1A mutants.

doi:10.1099/0022-1317-73-8-2135

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Article

Functional analysis of human papillomavirus type 16 E7 by complementation with adenovirus E1A mutants.

The Journal of general virology - 1 Aug 1992

Davies R C, Vousden K H

Abstract excerpt

Functional analysis of human papillomavirus type 16 E7 protein by complementation with adenovirus E1A mutants in baby rat kidney cells has shown that the retinoblastoma gene product (RB)-binding region of E7 can substitute in trans for that of E1A. An N-terminal E7 mutant was unable to complement...

Topics

Adenovirus Early Proteins
Animals
Antigens, Viral, Tumor
Cell Line
Genetic Complementation Test
Mutation
Oncogene Proteins, Viral
Papillomaviridae
Papillomavirus E7 Proteins
Plasmids
Precipitin Tests
Protein-Tyrosine Kinases
Retinoblastoma Protein

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