Silencing the type II sodium channel gene: a model for neural-specific gene regulation.

doi:10.1016/0896-6273(92)90218-3

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Article

Silencing the type II sodium channel gene: a model for neural-specific gene regulation.

Neuron - 1 Jul 1992

Kraner S D, Chong J A, Tsay H J, Mandel G

Abstract excerpt

Neural-specific expression of a sodium channel mini-gene has been shown to be mediated by a 28 bp silencer element, RE1, located in the 5' flanking region of the gene. This element is active exclusively in cell lines that do not express the endogenous brain type II sodium channel gene, including...

Topics

Adrenal Gland Neoplasms
Animals
Base Sequence
Cells, Cultured
DNA
DNA, Neoplasm
Deoxyribonucleases
Fibroblasts
Gene Expression Regulation
Genes, Regulator
Molecular Sequence Data
Muscles
Mutation
Neurons
Pheochromocytoma
Rats
Regulatory Sequences, Nucleic Acid
Sodium Channels

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