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Article

Synergy between the RE-1 Silencer of Transcription and NFκB in the Repression of the Neurotransmitter Gene TAC1 in Human Mesenchymal Stem Cells

21 Aug 2007

Abstract excerpt

The RE-1 silencer of transcription (REST) is a transcriptional regulator that represses neuron-specific genes in non-neuronal tissues by remodeling chromatin structure. We have utilized human mesenchymal stem cells (MSCs) as a research tool to understand the molecular mechanisms that regulate a neurogenic program of differentiation in non-neuronal tissue. MSCs are mesoderm-derived cells that generate specialized...

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PMID: 17709376
DOI: 10.1074/jbc.m703026200

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Synergy between the RE-1 Silencer of Transcription and NFκB in the Repression of the Neurotransmitter Gene TAC1 in Human Mesenchymal Stem CellsPMID 17709376Read ↗

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Effect of the ubiquitous transcription factors, SP1 and MAZ, on NMDA receptor subunit type 1 (NR1) expression during neuronal differentiation.Semantic proximity Read ↗

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