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Article

Insertional inactivation of a gene which controls expression of vancomycin resistance on plasmid pHKK100.

FEMS microbiology letters - 1 Apr 1992

Handwerger S, Discotto L, Thanassi J, Pucci M J

Abstract excerpt

Expression of inducible high level vancomycin resistance (Vmr) in enterococci appears to require other plasmid-encoded genes in addition to the previously described structural genes vanA and vanH. Tn917 mutagenesis was used to identify such a region in the Vmr plasmid pHKK100. Insertional inactivation of a 693-bp open reading frame upstream from vanH resulted in complete loss of Vmr. This putative 26,642-Da...

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PMID: 1320585
DOI: 10.1016/0378-1097(92)90533-t

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Insertional inactivation of a gene which controls expression of vancomycin resistance on plasmid pHKK100.PMID 1320585Read ↗

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