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Article

Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9.

Journal of bacteriology - 1 Oct 2010

Meziane-Cherif Djalal, Saul Frederick A, Moubareck Carole, Weber Patrick, Haouz Ahmed, Courvalin Patrice, Périchon Bruno

Abstract excerpt

The vancomycin-resistant Staphylococcus aureus VRSA-9 clinical isolate was partially dependent on glycopeptide for growth. The responsible vanA operon had the same organization as that of Tn1546 and was located on a plasmid. The chromosomal D-Ala:D-Ala ligase (ddl) gene had two point mutations that led to Q260K and A283E substitutions, resulting in a 200-fold decrease in enzymatic activity compared to that of the...

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Identifiers

PMID: 20729361
DOI: 10.1128/JB.00613-10
PMCID: PMC2950510

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