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Article

Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors.

Antimicrobial agents and chemotherapy - 1 Sept 1994

Arthur M, Depardieu F, Snaith H A, Reynolds P E, Courvalin P

Abstract excerpt

The vanR, vanS, vanH, vanA, and vanX genes of enterococcal transposon Tn1546 were introduced into the chromosome of Enterococcus faecalis JH2-2. Complementation of this portion of the van gene cluster by a plasmid encoding VanY D,D-carboxypeptidase led to a fourfold increase in the vancomycin MIC (from 16 to 64 micrograms/ml). Multicopy plasmids pAT80 (vanR vanS vanH vanA vanX) and pAT382 (vanR vanS vanH vanA...

Topics

Alanine
Amino Acid Sequence
Bacterial Proteins
Carbon-Oxygen Ligases
Carboxypeptidases
Cell Wall
Drug Resistance, Microbial
Enterococcus faecalis
Glycopeptides
Hydrolysis
Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Peptidoglycan

Phenotype

Vancomycin

Source

Open in PubMed Open full text

Identifiers

PMID: 7810996
DOI: 10.1128/AAC.38.9.1899
PMCID: PMC284659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7810996-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors.PMID 7810996Read ↗

Moderate-level resistance to glycopeptide LY333328 mediated by genes of the vanA and vanB clusters in enterococci.Semantic proximity Read ↗

Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147Semantic proximity Read ↗

Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp. The GenBank accession number for the 33803 bp sequence of Tn1549 is AJ192329.Semantic proximity Read ↗

Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.Semantic proximity Read ↗

Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.Semantic proximity Read ↗

Specificity of induction of glycopeptide resistance genes in Enterococcus faecalis.Semantic proximity Read ↗

Characterization of VanYn, a novel D,D‐peptidase/D,D‐carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727Semantic proximity Read ↗

The functional <scp><i>vanG<sub>Cd</sub></i></scp> cluster of <i><scp>C</scp>lostridium difficile</i> does not confer vancomycin resistanceSemantic proximity Read ↗

VanZ Reduces the Binding of Lipoglycopeptide Antibiotics to Staphylococcus aureus and Streptococcus pneumoniae CellsSemantic proximity Read ↗

Characterisation of VanA and VanB elements from glycopeptide-resistant Enterococcus faecium from Greece.Semantic proximity Read ↗

Reduction in glycopeptide resistance in vancomycin-resistant enterococci as a result of vanA cluster rearrangements.Semantic proximity Read ↗

The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction.Semantic proximity Read ↗

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