Article
The 30-base-pair deletion in Chinese variants of the Epstein-Barr virus LMP1 gene is not the major effector of functional differences between variant LMP1 genes in human lymphocytes.
Journal of virology - 1 May 1998
Johnson R J, Stack M, Hazlewood S A, Jones M, Blackmore C G, Hu L F, Rowe M
Abstract excerpt
One group of sequence variants of Epstein-Barr virus is characterized by a 10-amino-acid deletion within the CTAR-2 functional domain of the latent membrane protein, LMP1. A role for this deletion in enhancing the tumorigenicity of the viral oncogene in rodent fibroblasts was recently demonstrate...
Topics
- Amino Acid Sequence
- Base Composition
- CD40 Antigens
- China
- DNA, Viral
- Genes, Viral
- Genetic Variation
- Herpesvirus 4, Human
- Humans
- Intercellular Adhesion Molecule-1
- Lymphocytes
- Molecular Sequence Data
- NF-kappa B
- Sequence Deletion