Dietary supplements of antioxidants reduce hprt mutant frequency in splenocytes of aging mice.

doi:10.1016/0921-8734(95)00013-v

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Article

Dietary supplements of antioxidants reduce hprt mutant frequency in splenocytes of aging mice.

Mutation research - 1 Oct 1995

Gaziev A I, Podlutsky AJa, Panfilov B M, Bradbury R

Abstract excerpt

The level of spontaneous and gamma-radiation-induced mutations in the hypoxanthine-guanine phosphoribosyl-transferase (hprt) locus as well as the decrease in frequency of these mutations in mice of various age pretreated with dietary supplements of an antioxidant mixture (vitamins C, E, beta-carotene, rutin, selenium, zinc) were studied in splenocytes of young (8-14-week-old) and aged (102-110-week-old) male...

Topics

Aging
Animals
Antimutagenic Agents
Antioxidants
Ascorbic Acid
Carotenoids
Cells, Cultured
Diet
Gamma Rays
Hypoxanthine Phosphoribosyltransferase
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Mutation

Rutin

Selenium

Spleen

Zinc

Source

Open in PubMed

Identifiers

PMID: 7565884
DOI: 10.1016/0921-8734(95)00013-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7565884-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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