Article
Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase beta-subunit gene in mouse and human: tight linkage to the Huntington disease region (4p16.3).
Genomics - 1 Apr 1992
Altherr M R, Wasmuth J J, Seldin M F, Nadeau J H, Baehr W, Pittler S J
Abstract excerpt
The retinal degeneration mouse (gene symbol, rd) is an animal model for certain forms of human hereditary retinopathies. Recent findings of a nonsense mutation in the rd mouse PDE beta-subunit gene (Pdeb) prompted us to investigate the chromosome locations of the mouse and human genes. We have utilized backcross analysis in mice to verify and define more precisely the location of the Pdeb locus 6.1 +/- 2.3 cM...
Topics
- 3',5'-Cyclic-GMP Phosphodiesterases
- Animals
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- Genetic Linkage
- Humans
- Huntington Disease
- Mice
- Mutation
- Photoreceptor Cells
- Retinal Degeneration