Article
Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse.
European journal of human genetics : EJHG - 1 Jan 2000
Lorenz B, Migliaccio C, Lichtner P, Meyer C, Strom T M, D'Urso M, Becker J, Ciccodicola A, Meitinger T
Abstract excerpt
Rod-specific cGMP phosphodiesterase (PDE) is a key enzyme of the phototransduction cascade, and mutations in its catalytic subunits have been associated with retinal degenerative diseases. The bovine delta-subunit solubilises the normally membrane-bound PDE and is the only subunit expressed in ex...
Topics
- 3',5'-Cyclic-GMP Phosphodiesterases
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Chromosome Mapping
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Exons
- Humans
- Introns
- Mice
- Molecular Sequence Data
- Mutation