Article
Genetic mapping demonstrates that the alpha-subunit of retinal cGMP-phosphodiesterase is not the site of the rd mutation.
Experimental eye research - 1 Aug 1990
Danciger M, Kozak C A, Li T, Applebury M L, Farber D B
Abstract excerpt
In the inherited degenerative retinal disease of the rd mouse, rod cGMP levels rise above normal due to depressed cGMP-phosphodiesterase (cGMP-PDE) function a few days before degeneration begins. The subnormal activity of the cGMP-PDE may be due to a lesion in the enzyme itself, or in any of several proteins that regulate it. We have used a bovine cDNA for the alpha-subunit of cGMP-PDE to map its gene Pdea to...
Topics
- 3',5'-Cyclic-GMP Phosphodiesterases
- Animals
- Chromosome Mapping
- Mice
- Mice, Mutant Strains
- Mutation
- Retina
- Retinal Degeneration