Exclusion of DNA changes in the beta-subunit of the c-GMP phosphodiesterase gene as the cause for Huntington's disease.

doi:10.1038/ng0592-104

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Article

Exclusion of DNA changes in the beta-subunit of the c-GMP phosphodiesterase gene as the cause for Huntington's disease.

Nature genetics - 1 May 1992

Riess O, Noerremoelle A, Collins C, Mah D, Weber B, Hayden M R

Abstract excerpt

To identify expressed sequences within candidate regions for the Huntington's disease (HD) gene in 4p16.3, we isolated the gene encoding the beta subunit of the human cGMP phosphodiesterase (PDEB). We formally assessed this as a candidate gene for HD based on it's expression in brain, the demonst...

Topics

3',5'-Cyclic-GMP Phosphodiesterases
Base Sequence
DNA
DNA Mutational Analysis
Exons
Female
Gene Rearrangement
Humans
Huntington Disease
Male
Molecular Sequence Data
Pedigree
Phenotype
Polymorphism, Genetic

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