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Immunologic Control of Mus musculus Papillomavirus Type 1

23 Oct 2015

Abstract excerpt

Persistent papillomas developed in ~10% of out-bred immune-competent SKH-1 mice following MusPV1 challenge of their tail, and in a similar fraction the papillomas were transient, suggesting potential as a model. However, papillomas only occurred in BALB/c or C57BL/6 mice depleted of T cells with anti-CD3 antibody, and they completely regressed within 8 weeks after depletion was stopped. Neither CD4+ nor CD8+ T...

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PMID: 26495972
DOI: 10.1371/journal.ppat.1005243

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