Article
A procedure for selecting mammalian cells with an impairment in oxidative phosphorylation.
Biochimica et biophysica acta - 14 Apr 1992
Lombardo M C, van der Zwaan J W, Brul S, Tager J M
Abstract excerpt
The mitochondrial encephalomyopathies in man are characterized by heterogeneous defects leading to an impairment in the pathway of aerobic energy production. As a means of investigating the molecular and genetic mechanisms underlying these disorders we have developed a procedure for selecting mammalian cell lines with features resembling the human pathological phenotypes. The principle of the selection is the use...
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