Article
A procedure for selecting mammalian cells with an impairment in oxidative phosphorylation.
Biochimica et biophysica acta - 14 Apr 1992
Lombardo M C, van der Zwaan J W, Brul S, Tager J M
Abstract excerpt
The mitochondrial encephalomyopathies in man are characterized by heterogeneous defects leading to an impairment in the pathway of aerobic energy production. As a means of investigating the molecular and genetic mechanisms underlying these disorders we have developed a procedure for selecting mam...
Topics
- Animals
- Buthionine Sulfoximine
- CHO Cells
- Cell Separation
- Cell Survival
- Cricetinae
- Cytochrome-c Oxidase Deficiency
- Electron Transport Complex IV
- Electrophoresis
- Humans
- Immunoblotting
- Methionine Sulfoximine
- Mitochondria
- Mutation
- Oxidative Phosphorylation
- Phenotype
- Pyridinium Compounds
- Ultraviolet Rays