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Article

Analysis of constructed E gene mutants of mouse hepatitis virus confirms a pivotal role for E protein in coronavirus assembly.

Journal of virology - 1 Oct 1998

Fischer F, Stegen C F, Masters P S, Samsonoff W A

Abstract excerpt

Expression studies have shown that the coronavirus small envelope protein E and the much more abundant membrane glycoprotein M are both necessary and sufficient for the assembly of virus-like particles in cells. As a step toward understanding the function of the mouse hepatitis virus (MHV) E protein, we carried out clustered charged-to-alanine mutagenesis on the E gene and incorporated the resulting mutations...

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Identifiers

PMID: 9733825
DOI: 10.1128/JVI.72.10.7885-7894.1998
PMCID: PMC110113

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