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Article

Thrombin inhibits proliferation of the human megakaryoblastic MEG-01 cell line: a possible involvement of a cyclic-AMP dependent mechanism.

Journal of cellular physiology - 1 Jan 1992

Vittet D, Mathieu M N, Launay J M, Chevillard C

Abstract excerpt

Thrombin, a potent platelet activating agent, has previously been found to increase intracellular calcium levels and/or thromboxane A2 synthesis in leukemic cell lines exhibiting specific markers of the megakaryocyte/platelet lineage. However, its functional role on these cells has not been defin...

Topics

Calcium
Cell Differentiation
Cell Division
Cell Line
Cyclic AMP
Humans
Inositol Phosphates
Kinetics
Megakaryocytes
Phenotype
Thrombin

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Identifiers

PMID: 1309828
DOI: 10.1002/jcp.1041500110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1309828-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Thrombin inhibits proliferation of the human megakaryoblastic MEG-01 cell line: a possible involvement of a cyclic-AMP dependent mechanism.PMID 1309828Read ↗

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