Article
Chronic treatment with P2-purinergic receptor agonists induces phenotypic modulation of the HL-60 and U937 human myelogenous leukemia cell lines.
Journal of leukocyte biology - 1 Aug 1991
Cowen D S, Berger M, Nuttle L, Dubyak G R
Abstract excerpt
In previous studies we have demonstrated that extracellular ATP (and UTP), acting through P2-purinergic receptors, can stimulate the inositol phospholipid signaling system in neutrophils and monocytes, as well as in neutrophil/monocyte progenitor cells. In this study we have examined the ability of extracellular nucleotides to modulate the phenotype of myelomonocytic progenitor cells. As model systems, we...
Topics
- Actins
- Adenosine
- Adenosine Triphosphate
- Calcium
- Cell Differentiation
- Cell Division
- Cell Line
- Genes, myc
- Humans
- Kinetics
- Leukemia, Promyelocytic, Acute