Article
Androgen resistance due to mutation of the androgen receptor.
Clinical and investigative medicine. Medecine clinique et experimentale - 1 Oct 1992
Pinsky L, Trifiro M, Kaufman M, Beitel L K, Mhatre A, Kazemi-Esfarjani P, Sabbaghian N, Lumbroso R, Alvarado C, Vasiliou M
Abstract excerpt
The androgen receptor (AR) is a 'one-stop' signal transduction system that is the core of the intracellular androgen-response apparatus. It is an androgen-regulated, DNA-binding protein that regulates the expression of certain target genes, primarily at the transcriptional level. Mutations at the X-linked AR locus cause deficient or defective AR activity and, thereby, an extraordinarily wide spectrum of clinical...
Topics
- Amino Acid Sequence
- Androgens
- Animals
- Drug Resistance
- Female
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Receptors, Androgen
- Sex Differentiation