Variability of acetaminophen metabolism in Caucasians and Orientals.

doi:10.1097/00008571-199202000-00007

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Article

Variability of acetaminophen metabolism in Caucasians and Orientals.

Pharmacogenetics - 1 Feb 1992

Patel M, Tang B K, Kalow W

Abstract excerpt

Acetaminophen (paracetamol) is extensively conjugated with glucuronic acid and sulfate prior to renal excretion. A minor metabolic route involves microsomal oxidation of acetaminophen to a hepatotoxic reactive intermediate, which subsequently undergoes glutathione (GSH) conjugation, yielding cyst...

Topics

Acetaminophen
Asian People
Female
Genetic Variation
Gilbert Disease
Humans
Male
Sulfates
White People

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