Article
Illegitimate transcription: its use in the study of inherited disease.
Human mutation - 1 Jan 1992
Kaplan J C, Kahn A, Chelly J
Abstract excerpt
In 1988, by using the powerful and accurate cDNA/PCR technique, it was demonstrated that there are very low levels of dystrophin mRNA in a variety of non-muscle tissues, including cultured fibroblasts and lymphoblastoid cell lines. The phenomenon was also shown for a number of other tissue-specific genes, including beta-globin, factors VIIIc and IX, anti-Müllerian hormone, L-pyruvate kinase, retinal blue pigment,...
Topics
- Animals
- DNA
- Genetic Diseases, Inborn
- Humans
- Mutation
- Polymerase Chain Reaction
- RNA, Messenger
- Tissue Distribution
- Transcription, Genetic