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When Size <em>R</em><em>eally</em> Matters: The Eccentricities of Dystrophin Transcription and the Hazards of Quantifying mRNA from Very Long Genes

2023-06-29

Abstract excerpt

At 2.3 megabases in length, the dystrophin gene is enormous: transcription of a single mRNA requires approximately 16 hours. Principally expressed in skeletal muscle, the dystrophin protein product protects the muscle sarcolemma against contraction-induced injury, and dystrophin deficiency results in the fatal muscle-wasting disease, Duchenne muscular dystrophy. This gene is thus of key clinical interest, and ther...

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Literature Corpus work
12e61259-0500-5bc6-b104-4c4f37813794
DOI
10.20944/preprints202306.2167.v1
Open publication

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