Article
Illegitimate transcription: its use for studying genetic abnormalities in lymphoblastoid cells from patients with Glanzmann thrombasthenia.
British journal of haematology - 1 Jan 1998
Negrier C, Vinciguerra C, Attali O, Grenier C, Larcher M E, Dechavanne M
Abstract excerpt
Glanzmann thrombasthenia is the most common inherited disorder of platelets that may induce severe bleeding complications. Molecular biology techniques have offered the possibility to assess the basis of this chronic haemorrhagic disease at the molecular level. However, the accessibility of mRNA...
Topics
- Antigens, CD
- B-Lymphocytes
- Blood Platelets
- Cell Line, Transformed
- Flow Cytometry
- Humans
- Mutation
- Platelet Glycoprotein GPIIb-IIIa Complex
- RNA, Messenger
- Thrombasthenia
- Transcription, Genetic