Article
Frequency of replication/transcription errors in (A)/(T) runs of human genes.
Human genetics - 1 Jul 2001
Paoloni-Giacobino A, Rossier C, Papasavvas M P, Antonarakis S E
Abstract excerpt
To estimate the error rate of the gene expression machinery and its possible age-related increase, we compared the occurrence of polymerase errors during replication and transcription in (A)/(T) runs, in DNA and RNA of young and old individuals and of early- and late-passage cultured fibroblasts. We analyzed three human genes: TPRD, TGFBR2, and ATRX containing stretches of (A)8, (A)10, and (T)13, respectively....
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