Article
Animal models of tyrosinemia.
The Journal of nutrition - 1 Jun 2007
Nakamura Kimitoshi, Tanaka Yasuhiko, Mitsubuchi Hiroshi, Endo Fumio
Abstract excerpt
Hereditary tyrosinemia I (HT I) is a genetic disorder of tyrosine metabolism characterized by progressive liver damage from infancy and by a high risk for hepatocellular carcinoma. HT I is due to mutations in the fumarylacetoacetate hydrolase (Fah) gene, which encodes the last enzyme in the tyrosine catabolic pathway. Disturbances in tyrosine metabolism lead to increased levels of succinylacetone and...
Topics
- Animals
- Apoptosis
- Cytochromes c
- Disease Models, Animal
- Immunoglobulin Variable Region
- Kidney Tubules
- Liver Regeneration
- Mice
- Mice, Mutant Strains
- Mitochondria, Liver
- Mutation
- Phenotype
- Tyrosinemias