Article
Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection--association between TGF-beta1 polymorphisms and hepatocellular carcinoma.
Journal of hepatology - 1 Apr 2005
Migita Kiyoshi, Miyazoe Seiji, Maeda Yumi, Daikoku Manabu, Abiru Seigo, Ueki Tshihito, Yano Koji, Nagaoka Shinya, Matsumoto Takehiro, Nakao Kazuhiko, Hamasaki Keisuke, Yatsuhashi Hiroshi, Ishibashi Hiromi, Eguchi Katsumi
Abstract excerpt
BACKGROUND/AIMS: In this study, we determined the frequencies of the genotypes associated with the polymorphism of the cytokines genes, and investigated their association with the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) carriers. METHODS: Genetic polymorphism in the cytokines TNF-alpha, IFN-gamma, TGF-beta1, IL-6, and IL-10 were studied in 236 Japanese patients with HBV infection. The...
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