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Article

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method.

Pharmacogenetics - 1 Jul 2000

Ozdemir V, Kalow W, Tang B K, Paterson A D, Walker S E, Endrenyi L, Kashuba A D

Abstract excerpt

The CYP3A4 enzyme contributes to the disposition of more than 60 therapeutically important drugs and displays marked person-to-person variability of the catalytic function. However, the extent of genetic contribution to variability in CYP3A4 activity remains elusive. Recently, we showed that a comparison of between- (SDb2) and within-person (SDW2) variances provides an estimate of the genetic component of...

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PMID: 10898107
DOI: 10.1097/00008571-200007000-00001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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