Article
TGF-beta control of rat thyroid follicular cells differentiation.
Molecular and cellular endocrinology - 30 Sept 2003
Nicolussi Arianna, D'Inzeo Sonia, Santulli Maria, Colletta Giulia, Coppa Anna
Abstract excerpt
TGF-beta1 is a potent inhibitor of growth and DNA synthesis in thyroid cells. It has also been shown that TGF-beta1 inhibits thyrocyte function. The functional inhibition is represented by a downregulation of thyroid specific genes, such as Na(+)/I(-) symporter (NIS), thyroglobulin (TG) and thyro...
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