Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tolerance induction by costimulator blockade in 100 cGy treated hosts with varying degrees of genetic disparity.

Leukemia - 1 Sept 2003

Abedi M, Greer D, Lambert J F, Colvin G A, Dooner M S, McAuliffe C I, Demers D, Moore B E, Quesenberry P J

Abstract excerpt

Long-term multilineage allochimerism can be obtained in H2-mismatched B6.SJL to BALB/c transplants with host irradiation of 100 cGy, donor spleen cell pre-exposure and costimulator blockade with anti-CD40 ligand (CD40L) antibody. We evaluated this allochimerism approach in murine marrow transplants with different degrees of major histocompatibility complexe (MHC) mismatching; these include: (1) H2-mismatched...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD40 Ligand
Share to Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Graft Survival

Share to H-2 Antigens

Share to Mice, Inbred CBA

Share to Transplantation Chimera

Share to Transplantation Tolerance

Share to Whole-Body Irradiation

Source

Identifiers

PMID: 12970789
DOI: 10.1038/sj.leu.2403070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tolerance induction by costimulator blockade in 100 cGy treated hosts with varying degrees of genetic disparity.PMID 12970789Read ↗

A nonlethal conditioning approach to achieve durable multilineage mixed chimerism and tolerance across major, minor, and hematopoietic histocompatibility barriersSemantic proximity Read ↗

Stem cell engraftment strategies.Semantic proximity Read ↗

Allogeneic MHC-mismatched activated natural killer cells administered after bone marrow transplantation provide a strong graft-versus-leukaemia effect in mice.Semantic proximity Read ↗

CD45 congenic bone marrow transplantation: evidence for T cell-mediated immunity.Semantic proximity Read ↗

THYMIC DEPENDENCE OF LOSS OF TOLERANCE IN MIXED ALLOGENEIC BONE MARROW CHIMERAS AFTER DEPLETION OF DONOR ANTIGENSemantic proximity Read ↗

Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation.Semantic proximity Read ↗

Immunosenescence does not abrogate engraftment of murine allogeneic bone marrow.Semantic proximity Read ↗

Chimerism and tolerance in transplantationSemantic proximity Read ↗

Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioningSemantic proximity Read ↗

Mechanism for cotolerance in nonlethally conditioned mixed chimeras: negative selection of the Vbeta T-cell receptor repertoire by both host and donor bone marrow-derived cellsSemantic proximity Read ↗

Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts.Semantic proximity Read ↗

Antibody targeting KIT as pretransplantation conditioning in immunocompetent miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.