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Article

FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice.

Blood - 1 Jan 2004

Guasch Geraldine, Delaval Bénédicte, Arnoulet Christine, Xie Min-Jue, Xerri Luc, Sainty Danielle, Birnbaum Daniel, Pébusque Marie-Joséphe

Abstract excerpt

Constitutive activation of aberrant fibroblast growth factor receptor 1 (FGFR1) kinase as a consequence of gene fusion such as FOP-FGFR1 associated with t(6; 8)(q27;p11-12) translocation, is the hallmark of an atypical aggressive stem cell myeloproliferative disorder (MPD) in humans. In this study, we show that expression of FOP-FGFR1 in primary bone marrow cells induced by retroviral transduction generates a MPD...

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Share to Bone Marrow Transplantation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Receptor Protein-Tyrosine Kinases

Share to Receptors, Fibroblast Growth Factor

Share to Transduction, Genetic

Share to Translocation, Genetic

Source

Identifiers

PMID: 12969958
DOI: 10.1182/blood-2003-05-1690

Genes

FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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