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Article

The t(6;8)(q27;p11) Translocation in a Stem Cell Myeloproliferative Disorder Fuses a Novel Gene, FOP, to Fibroblast Growth Factor Receptor 1

15 Feb 1999

Abstract excerpt

In patients with an atypical stem-cell myeloproliferative disorder with lymphoma (B or T cell), myeloid hyperplasia, and eosinophilia, the chromosome 8p11-12 region is the site of a recurrent breakpoint that can be associated with three different partners, 6q27, 9q32-34, and 13q12. Rearrangements are supposed to affect a pluripotent stem cell capable of myeloid and lymphoid differentiation and to involve the same...

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Identifiers

PMID: 9949182
DOI: 10.1182/blood.v93.4.1381

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The t(6;8)(q27;p11) Translocation in a Stem Cell Myeloproliferative Disorder Fuses a Novel Gene, FOP, to Fibroblast Growth Factor Receptor 1PMID 9949182Read ↗

Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12)Semantic proximity Read ↗

The 8p11 Myeloproliferative Syndrome: A Distinct Clinical Entity Caused by Constitutive Activation of <i>FGFR1</i>Semantic proximity Read ↗

FGFR1 is fused to the centrosome-associated proteinCEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)Semantic proximity Read ↗

Identification of a novel partner gene, <i>TPR</i>, fused to <i>FGFR1</i> in 8p11 myeloproliferative syndromeSemantic proximity Read ↗

Identification of a novel gene, <i>FGFR1OP2</i>, fused to <i>FGFR1</i> in 8p11 myeloproliferative syndromeSemantic proximity Read ↗

Fusion of the <i>BCR</i> and the fibroblast growth factor receptor‐1 (<i>FGFR1</i>) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: The first fusion gene involving <i>BCR</i> but not <i>ABL</i>Semantic proximity Read ↗

FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice.Semantic proximity Read ↗

The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre‐mRNA processing proteins <i>SFPQ (PSF)</i> and <i>CPSF6</i> to <i>ABL</i> and <i>FGFR1</i>Semantic proximity Read ↗

LRRFIP1, a new FGFR1 partner gene associated with 8p11 myeloproliferative syndromeSemantic proximity Read ↗

8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes.Semantic proximity Read ↗

Biphenotypic hematologic malignancy: a case report of the 8p11 myeloproliferative syndrome in a child.Semantic proximity Read ↗

Consistent Fusion of ZNF198 to the Fibroblast Growth Factor Receptor-1 in the t(8;13)(p11;q12) Myeloproliferative SyndromeSemantic proximity Read ↗

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