Article
Ent3p Is a PtdIns(3,5)P2 effector required for protein sorting to the multivesicular body.
Developmental cell - 1 Sept 2003
Friant Sylvie, Pécheur Eve Isabelle, Eugster Anne, Michel Fabrice, Lefkir Yaya, Nourrisson Delphine, Letourneur François
Abstract excerpt
PtdIns(3,5)P(2) is required for cargo-selective sorting to the vacuolar lumen via the multivesicular body (MVB). Here we show that Ent3p, a yeast epsin N-terminal homology (ENTH) domain-containing protein, is a specific PtdIns(3,5)P(2) effector localized to endosomes. The ENTH domain of Ent3p is essential for its PtdIns(3,5)P(2) binding activity and for its membrane interaction in vitro and in vivo. Ent3p is...
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