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Article

Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2006

Aguilar Rubén C, Longhi Silvia A, Shaw Jonathan D, Yeh Lan-Yu, Kim Sean, Schön Arne, Freire Ernesto, Hsu Ariel, McCormick William K, Watson Hadiya A, Wendland Beverly

Abstract excerpt

Epsins are endocytic proteins with a structured epsin N-terminal homology (ENTH) domain that binds phosphoinositides and a poorly structured C-terminal region that interacts with ubiquitin and endocytic machinery, including clathrin and endocytic scaffolding proteins. Yeast has two redundant genes encoding epsins, ENT1 and ENT2; deleting both genes is lethal. We demonstrate that the ENTH domain is both necessary...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to cdc42 GTP-Binding Protein, Saccharomyces cerevisiae

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Identifiers

PMID: 16537494
DOI: 10.1073/pnas.0510513103
PMCID: PMC1449656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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