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Article

Survival regulation in pancreatic cancer cells by c-Jun.

International journal of oncology - 1 Oct 2003

Okutomi Yoshiyuki, Shino Yuji, Komoda Fumitake, Hirano Tatsuya, Ishihara Takeshi, Yamaguchi Taketo, Saisho Hiromitsu, Shirasawa Hiroshi

Abstract excerpt

Over 90% of human pancreatic cancers harbor an activating point mutation in the K-ras gene at codon 12. However, it is not clear whether all downstream K-ras are activated and which downstream contributes to the cell survival and proliferation of pancreatic cancer cells. MEK kinase 1 (MEKK1)-c-Jun N-terminal kinase (JNK)-c-Jun pathway has an important role in cell proliferation, survival and apoptosis in various...

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PMID: 12963995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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