Article
Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.
Biochemical and biophysical research communications - 17 Apr 2009
Wilder Phillip J, Chakravarthy Harini, Hollingsworth Michael A, Rizzino Angie
Abstract excerpt
There is a pressing need for new therapies to treat pancreatic cancer. In principle, this could be achieved by taking advantage of signaling pathways that are active in tumor, but not normal, cells. The work described in this study set out to determine whether the activities of three enhancers, which have been reported to be highly responsive to activated ras, differ in pancreatic tumor cells that express...
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