Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.

doi:10.1016/j.bbrc.2009.02.126

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Article

Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.

Biochemical and biophysical research communications - 17 Apr 2009

Wilder Phillip J, Chakravarthy Harini, Hollingsworth Michael A, Rizzino Angie

Abstract excerpt

There is a pressing need for new therapies to treat pancreatic cancer. In principle, this could be achieved by taking advantage of signaling pathways that are active in tumor, but not normal, cells. The work described in this study set out to determine whether the activities of three enhancers, w...

Topics

Culture Media
Enhancer Elements, Genetic
Humans
Mutation
Pancreatic Neoplasms
Proto-Oncogene Proteins p21(ras)
Signal Transduction
ras Proteins

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